Phosphoramide mustard

• Description :

  Phosphoramide mustard is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard induces DNA damage[1][2].

• CAS Number :

  [10159-53-2]

• UNSPSC :

  12352211

• Hazard Statement :

  H301-H311-H331-H341

• Target :

  DNA Alkylator/Crosslinker; Drug Metabolite

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/phosphoramide-mustard.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=P(N(CCCl)CCCl)(N)O

• Molecular Formula :

  C4H11Cl2N2O2P

• Molecular Weight :

  221.02

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501

• References & Citations :

  [1]Shanthi Ganesan, et al. Phosphoramide mustard exposure induces DNA adduct formation and the DNA damage repair response in rat ovarian granulosa cells. Toxicol Appl Pharmacol. 2015 Feb 1; 282 (3) : 252–258.|[2]S Genka, et al. Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat. Cancer Chemother Pharmacol. 1990;27 (1) :1-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Citation 01 :

  SSRN. 2024 Mar 21.|Stem Cell Res Ther. 2024 Apr 5;15 (1) :97.|Climacteric. 2025 Jan 10:1-12.|Int J Nanomedicine. 2025 Aug 22:20:10195-10212.|J Funct Foods. 2025 Jun.|Sci Rep. 2024 Aug 16;14 (1) :19008.|Tufts University. 2025.