Products for Research Use Only
RegisterLogin

DM1-PEG4-DBCO

CAT: 0804-HY-136261-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-136261-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DM1- (PEG) 4-DBCO is a agent-linker conjugate composed of a potent microtubulin inhibitor DM1 and a linker DBCO-PEG4-Ahx to make antibody agent conjugate (ADC) . Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DM1-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dm1-peg4-dbco.html
Purity
98.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC(C/C(C)=C/C=C/[C@@H](OC)[C@]2(O)NC(O[C@@]([C@@H](C)[C@@](O3)([H])[C@]3(C)[C@@H](OC([C@H](C)N(C)C(CCCOCCOCCOCCOCCNC(CCC(N4CC(C=CC=C5)=C5C#CC6=C4C=CC=C6)=O)=O)=O)=O)CC7=O)([H])C2)=O)=CC(N7C)=C1Cl
Molecular Formula
C63H80ClN5O16
Molecular Weight
1198.79
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Maytansinoids

Related Products

CatalogName
HY-136260DBCO-PEG4-Ahx-DM1
HY-130346-01DBCO-PEG4-DBCO
HY-120770-01DBCO-PEG4-Maleimide
HY-136049APN-PEG4-DBCO
HY-133430DBCO-PEG4-alkyne
HY-133492-01DBCO-PEG4-MMAF
HY-140308-01DBCO-PEG4-triethoxysilane
HY-130435-01DBCO-PEG4-amine
HY-180568Bromoacetamide-PEG4-DBCO
HY-140310TCO-PEG4-DBCO

Alternative Products

CatalogName
T17832-01DM1-PEG4-DBCO
MBS5770662DBCO-PEG4-Ahx-DM1
TRC-D489670-10MGDM1-MCC-PEG4-DBCO
GTR19248974-01DBCO-PEG4-VC-PAB-Ahx-DM1
MBS5768950DBCO-PEG4-DBCO
GTR19155124DM1- (PEG) 4-DBCO
BA2690-1DBCO-PEG4-MMAF
BA2540-5DBCO-PEG4-amine
CLK-033-SDBCO-PEG4-FLAG
BXC86388-01TCO-PEG4-DBCO

Popular Products