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DM1-PEG4-DBCO

CAT: 0931-T17832-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T17832-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
DM1- (PEG) 4-DBCO is a drug-linker conjugate that combines the potent microtubulin inhibitor mertansine (DM1) with the DBCO-PEG4-Ahx linker for developing antibody-drug conjugates (ADCs) . This conjugation aims to mitigate systemic toxicity associated with maytansine while improving tumor-specific delivery, leveraging DM1's ability as an antibody-conjugatable maytansinoid.
Smiles
COC1=CC(C/C(C)=C/C=C/[C@@H](OC)[C@]2(O)NC(OC([C@@H](C)C(O3)[C@]3(C)[C@@H](OC([C@H](C)N(C)C(CCCOCCOCCOCCOCCNC(CCC(N4CC(C=CC=C5)=C5C#CC6=C4C=CC=C6)=O)=O)=O)=O)CC7=O)C2)=O)=CC(N7C)=C1Cl
Molecular Formula
C63H80ClN5O16
Molecular Weight
1198.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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MBS5770702DM1-PEG4-DBCO
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