RepSox (GMP)

• Description :

  RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor[1].

• Product Name Alternative :

  E-616452 (GMP) ; SJN 2511 (GMP)

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  TGF-β Receptor

• Type :

  GMP Small Molecules

• Related Pathways :

  TGF-beta/Smad

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/repsox-gmp.html

• Purity :

  99.0

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1

• Molecular Formula :

  C17H13N5

• Molecular Weight :

  287.32

• Precautions :

  H301

• References & Citations :

  [1]Zhao T, et al. Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming. Cell Stem Cell. 2018 Jul 5;23 (1) :31-45.e7. |[2]Guan J, et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022 May;605 (7909) :325-331. |[3]Bar-Nur O, et al. Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 May 8;10 (5) :1505-1521.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  4°C, sealed storage, away from moisture and light

• Scientific Category :

  GMP Small Molecules

• Clinical Information :

  No Development Reported

• CAS Number :

  [446859-33-2]