RepSox

• Description :

  RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes[1][2].

• Product Name Alternative :

  E-616452; SJN 2511

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  Organoid; TGF-β Receptor

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/RepSox.html

• Purity :

  99.92

• Solubility :

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles :

  CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1

• Molecular Formula :

  C17H13N5

• Molecular Weight :

  287.32

• Precautions :

  H301

• References & Citations :

  [1]Gellibert F, et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47 (18) :4494-506.|[2]Wan-Zhi Tu, et al. RepSox, a small molecule inhibitor of the TGFβ receptor, induces brown adipogenesis and browning of white adipocytes. Acta Pharmacol Sin. 2019 Dec;40 (12) :1523-1531.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ALK5

• CAS Number :

  [446859-33-2]