RepSox (hydrochloride)

• Description :

  RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5) . RepSox hydrochloride inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox hydrochloride can be used in the study of obesity and related metabolic diseases such as type 2 diabetes.

• Product Name Alternative :

  E-616452 (hydrochloride) ; SJN 2511 (hydrochloride)

• UNSPSC :

  12352005

• Target :

  Anaplastic lymphoma kinase (ALK) ; TGF-beta/Smad

• Related Pathways :

  Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Smiles :

  CC1=NC(C2=NNC=C2C3=CC=C4N=CC=CC4=N3)=CC=C1.Cl

• Molecular Formula :

  C17H14ClN5

• Molecular Weight :

  323.78

• References & Citations :

  [1]Gellibert F, et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47 (18) :4494-506.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2319939-07-4]