Recombinant Rat SDF-1 Alpha/CXCL12 Alpha protein

• Background:

  CXCL12 also known as SDF-1 is belonging to the CXC chemokine family. Rat CXCL12 is expressed as two isoforms that differ only in the C-terminal tail. And both SDF-1 isoforms undergo proteolytic processing of the first two N-terminal amino acids. Contrast to SDF-1β, SDF-1α is shorter by four amino acids at the C-terminal tail. On the cell surface, the receptor for this chemokine is CXCR4 and syndecan4. CXCL12 is strongly chemotactic for T-lymphocytes, monocytes, but not neutrophils. SDF-1 is highly conserved between species, rat CXCL12α shares approximately 96 % amino acid sequence identity with human CXCL12α.

• CAS Number:

  9000-83-3

• Reconstitution:

  Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.

• Molecular Weight:

  Approximately 7.9 kDa, a single non-glycosylated polypeptide chain containing 68 amino acids.