SDF-1 alpha (CXCL12)

• Description:

  SDF-1α and β are stromal derived CXC chemokines, and signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV suppressive activity in cells expressing the CXCR4 receptor. Recombinant murine SDF-1α is a 7.9 kDa protein containing 68 amino acid residues.

• Synonyms:

  Pxorf31

• NCBI Gene ID:

  912189

• UniProt:

  P40224

• Accession Number:

  NP_068350.1

• Accession Number mRNA:

  NM_021704

• Chromosomal Location:

  6 F1; 6 53.0 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Rat, Mouse, Leech

• Sequence:

  KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human peripheral blood monocytes using a concentration of 50-100 ng/ml.

• Length:

  68

• Form:

  Lyophilized

• Molecular Weight:

  7.9 kDa

• Host or Source:

  E. coli