Recombinant Rat TNF-Alpha protein

Recombinant Rat TNF-Alpha protein

• Background: Tumor necrosis factor alpha (TNF-α), also called cachectin, is the best-know member of the TNF-family, which can cause cell death. This protein is produced by neutrophils, activated lymphocytes, macrophages, NK cells, LAK cells, astrocytes endothelial cells, smooth muscle cells and some transformed cells. TNF-α occurs as a secreted, soluble form and as a membrane-anchored form, both of which are biologically active. The naturally-occurring form of TNF-α is glycosylated, but non-glycosylated recombinant TNF-α has comparable biological activity. Two types of receptors for TNF-α have been described and virtually all cell types studied show the presence of one or both of these receptor types.
• CAS Number: 9000-83-3
• Reconstitution: Lyophilized from a .2 μm filtered solution of PBS, pH 7.4.
• Molecular Weight: Approximately 17.2 kDa, a single non-glycosylated polypeptide chain containing 156 amino acids.