Products for Research Use Only
RegisterLogin

PR-924

CAT: 0804-HY-123587-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-123587-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. PR-924 covalently modifies proteasomal N-terminal threonine active sites. PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities[1][2].
CAS Number
1416709-79-9
UNSPSC
12352005
Target
Apoptosis; Proteasome
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pr-924.html
Purity
98.87
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC1=CC=CC=C1)C([C@]2(CO2)C)=O)[C@@H](NC([C@@H](C)NC(C(CC3=CC=CC=C43)=C4C)=O)=O)CC5=CNC6=CC=CC=C56
Molecular Formula
C37H38N4O5
Molecular Weight
618.72
References & Citations
[1]Singh AV, et al. PR-924, a selective inhibitor of the immunoproteasome subunit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivo. Br J Haematol. 2011 Jan;152 (2) :155-63.|[2]Parlati F, et al. Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood. 2009 Oct 15;114 (16) :3439-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-RI02510-01Hsa-miR-924 inhibitor
HY-RI02510A-01Hsa-miR-924 antagomir
HY-R02510-01Hsa-miR-924 mimic
HY-R02510A-01Hsa-miR-924 agomir
HY-13814-01PR-619
HY-16405-01PR-104
HY-14572-01PR-104A
HY-P1259PR-39
HY-157493-01PR antagonist 1
HY-P74613-01PR-Set7, Human

Alternative Products

CatalogName
RGC70979-01PR-924
MBS5776194A 924
T30917-01CI 924
MPH02019hsa-miR-924 Primers
MBS8311378-01hsa-miR-924 miRNA Agomir
MBS8293483-01hsa-miR-924 miRNA Inhibitor
MBS8316625-01hsa-miR-924 miRNA Antagomir
GTR19320803-01Hsa-miR-924 miRNA Mimic

Popular Products