PR-104

CAT: 0804-HY-16405-01Size: 5 mgDry Ice: YesHazardous: No
CAT#:0804-HY-16405-01Size:5 mg
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Description
PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A[1].
CAS Number
[851627-62-8]
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pr-104.html
Purity
97.71
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NCCOP(O)(O)=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCOS(=O)(C)=O
Molecular Formula
C14H20BrN4O12PS
Molecular Weight
579.27
References & Citations
[1]Patterson AV, et al. Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin Cancer Res. 2007;13 (13) :3922-3932.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light, stored under nitrogen
Scientific Category
Reference compound1
Clinical Information
Phase 2

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