PR-104

• Description :

  PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A[1].

• UNSPSC :

  12352005

• Target :

  DNA Alkylator/Crosslinker

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pr-104.html

• Purity :

  97.71

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(NCCOP(O)(O)=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCOS(=O)(C)=O

• Molecular Formula :

  C14H20BrN4O12PS

• Molecular Weight :

  579.27

• References & Citations :

  [1]Patterson AV, et al. Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin Cancer Res. 2007;13 (13) :3922-3932.

• Shipping Conditions :

  Dry Ice

• Storage Conditions :

  -80°C, protect from light, stored under nitrogen

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [851627-62-8]