PR-104

• Description:

  PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A[1].

• UNSPSC:

  12352005

• Target:

  DNA Alkylator/Crosslinker

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pr-104.html

• Purity:

  97.71

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(NCCOP(O)(O)=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCOS(=O)(C)=O

• Molecular Formula:

  C14H20BrN4O12PS

• Molecular Weight:

  579.27

• References & Citations:

  [1]Patterson AV, et al. Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin Cancer Res. 2007;13 (13) :3922-3932.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  -80°C, protect from light, stored under nitrogen

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [851627-62-8]