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Cevimeline (hydrochloride)

CAT: 0804-HY-70020B-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-70020B-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia[1][2][3][4]. Cevimeline hydrochloride can cross the blood-brain barrier (BBB) [5].
CAS Number
107220-28-0
Product Name Alternative
AF102B (hydrochloride)
UNSPSC
12352005
Hazard Statement
H301
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Cevimeline-hydrochloride.html
Purity
98.74
Solubility
10 mM in DMSO|H2O : ≥ 50 mg/mL
Smiles
C[C@H]1SC[C@@]2(CN3CCC2CC3)O1.Cl
Molecular Formula
C10H18ClNOS
Molecular Weight
235.77
Precautions
H301
References & Citations
[1]Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34 (8) :1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9.|[2]Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57 (4) :421-8. Epub 2011 Nov 17.|[3]Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337 (1) :267-74. Epub 2011 Jan 14.|[4]Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7 (1) :57-9.|[5]Mitoh Y, et al. Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats. Auton Neurosci. 2017 Sep;206:1-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAChR1; mAChR3
Citation 01
Cancer Cell. 2025 Aug 12:S1535-6108 (25) 00330-7.|Cell Rep. 2025 Sep 18.

Chemical Information

(2R,3'R)-2-methyl-1'-azaspiro((1,3)oxathiolane-5,3'-bicyclo(2.2.2)octane) hydrochloride
CAS Number107220-28-0
PubChem CID123603
IUPAC Name(2R,5R)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane];hydrochloride
Molecular FormulaC10H18ClNOS
Molecular Weight235.77
Topological Polar Surface Area37.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Heavy Atom Count14
Formal Charge0
Complexity215
SMILES
C[C@@H]1O[C@]2(CN3CCC2CC3)CS1.Cl
InChI
InChI=1S/C10H17NOS.ClH/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;/h8-9H,2-7H2,1H3;1H/t8-,10-;/m1./s1
InChIKey
SURWTGAXEIEOGY-GHXDPTCOSA-N
Chemical Structure
2D Structure
2D structure of (2R,3'R)-2-methyl-1'-azaspiro((1,3)oxathiolane-5,3'-bicyclo(2.2.2)octane) hydrochloride
CAS: 107220-28-0
CID: 123603
Formula: C10H18ClNOS
MW: 235.77
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight235.77
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass235.0797631
Monoisotopic Mass235.0797631
Topological Polar Surface Area37.8 Ų
Heavy Atom Count14
Formal Charge0
Complexity215
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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