Cevimeline (hydrochloride)

CAT: 0804-HY-70020B-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-70020B-01Size:5 mg
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Description
Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia[1][2][3][4]. Cevimeline hydrochloride can cross the blood-brain barrier (BBB) [5].
CAS Number
[107220-28-0]
Product Name Alternative
AF102B (hydrochloride)
UNSPSC
12352005
Hazard Statement
H301
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Cevimeline-hydrochloride.html
Purity
98.74
Solubility
10 mM in DMSO|H2O : ≥ 50 mg/mL
Smiles
C[C@H]1SC[C@@]2(CN3CCC2CC3)O1.Cl
Molecular Formula
C10H18ClNOS
Molecular Weight
235.77
Precautions
H301
References & Citations
[1]Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34 (8) :1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9.|[2]Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57 (4) :421-8. Epub 2011 Nov 17.|[3]Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337 (1) :267-74. Epub 2011 Jan 14.|[4]Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7 (1) :57-9.|[5]Mitoh Y, et al. Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats. Auton Neurosci. 2017 Sep;206:1-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAChR1; mAChR3
Citation 01
Cancer Cell. 2025 Aug 12:S1535-6108 (25) 00330-7.|Cell Rep. 2025 Sep 18.

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