(KO Validated) TYSY Polyclonal Antibody

CAT: 0866-RD89442A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD89442A-01Size:60 μL
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Background
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
Description
This is a (KO Validated) TYSY Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
TYMS, HST422, TMS, TS, thymidylate synthase
Gene ID
7298
Swiss Prot
P04818
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human TYSY
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:200, IF 1:50-1:200
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
8kDa/11kDa
Observed Molecular Weight
16KDa/80KDa
Host or Source
Rabbit
Isotype
IgG

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