Products for Research Use Only
RegisterLogin

MS437

CAT: 0804-HY-114994-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-114994-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MS437 is a potent TSH receptor (TSHR) stimulator with an EC50 value of 13x10-8 M. MS437 shows potent activation of Gsα, Gαq and Gα12 and up-regulation of thyroglobulin (Tg), sodium iodine symporter (NIS) and TSHR gene expressions[1].
CAS Number
541535-31-3
Product Name Alternative
HMR-1275; Alvocidib; L86-8275
UNSPSC
12352005
Target
TSH Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ms437.html
Purity
98.0
Smiles
O=C(C1=C2C(C=CC=C2)=NC(C3=CC=CC=C3)=C1)N(C(C)C)C(C)C
Molecular Formula
C22H24N2O
Molecular Weight
332.44
References & Citations
[1]Latif R, et al. New small molecule agonists to the thyrotropin receptor. Thyroid. 2015 Jan;25 (1) :51-62.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide
CAS Number541535-31-3
PubChem CID803083
IUPAC Name2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide
Molecular FormulaC22H24N2O
Molecular Weight332.4
XLogP4.9
Topological Polar Surface Area33.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity433
SMILES
CC(C)N(C(C)C)C(=O)C1=CC(=NC2=CC=CC=C21)C3=CC=CC=C3
InChI
InChI=1S/C22H24N2O/c1-15(2)24(16(3)4)22(25)19-14-21(17-10-6-5-7-11-17)23-20-13-9-8-12-18(19)20/h5-16H,1-4H3
InChIKey
LXECNSUVDZQPHW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-phenyl-N,N-di(propan-2-yl)quinoline-4-carboxamide
CAS: 541535-31-3
CID: 803083
Formula: C22H24N2O
MW: 332.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight332.4
XLogP34.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass332.188863393
Monoisotopic Mass332.188863393
Topological Polar Surface Area33.2 Ų
Heavy Atom Count25
Formal Charge0
Complexity433
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-13959-01MS436
HY-130602-01MS432
HY-111139-01MS417
HY-114918-01MS438
HY-115873Folate-MS432
HY-RS08705MS4A7 Human Pre-designed siRNA Set A
HY-RS21656Ms4a7 Mouse Pre-designed siRNA Set A
HY-RS28174Ms4a7 Rat Pre-designed siRNA Set A

Alternative Products

CatalogName
MBS5774254MS437

Popular Products