MS438

CAT: 0804-HY-114918-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-114918-01Size:5 mg
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Description
MS438 is a potent thyrotropin receptor (TSHR) agonist with an EC50 of 53 nM. MS438 binds to the serpentine portion of the TSHR. MS438 induces T4 secretion in mice[1].
CAS Number
[512840-45-8]
Product Name Alternative
1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3
UNSPSC
12352005
Target
TSH Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ms438.html
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(OCC1=CC=CC=C1)C2=C(NC(NC2C3=CC=C(C=C3)C(F)(F)F)=O)C
Molecular Formula
C20H17F3N2O3
Molecular Weight
390.36
References & Citations
[1]Latif R, et al. New small molecule agonists to the thyrotropin receptor. Thyroid. 2015 Jan;25 (1) :51-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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