Folate-MS432

• Description :

  Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells.

• UNSPSC :

  12352005

• Target :

  PROTACs

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/folate-ms432.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCCCCCCCNCCCONC(C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F)=O)=O)=O)C[C@H](OC(CCCCN4C=C(CNC(CC[C@H](NC(C5=CC=C(C=C5)NCC6=CN=C7NC(N)=NC(C7=N6)=O)=O)C(O)=O)=O)N=N4)=O)C1)N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C

• Molecular Formula :

  C77H94F3IN18O12S

• Molecular Weight :

  1679.65

• References & Citations :

  [1]Liu J, et al. Cancer Selective Target Degradation by Folate-Caged PROTACs. J Am Chem Soc. 2021 May 19;143 (19) :7380-7387.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2769735-56-8]