Oligomycin A

• Description:

  Oligomycin A (MCH 32), created by Streptomyces, acts as a mitochondrial F0F1-ATPase inhibitor, with a Ki of 1 μM; Oligomycin A shows anti-fungal activity.

• Product Name Alternative:

  MCH 32

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Antibiotic; ATP Synthase; Fungal

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/Oligomycin_A.html

• Purity:

  99.94

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic; heat to 60°C)

• Smiles:

  O=C (/C=C/[C@H] (C) [C@@H] (O) [C@H] (C) C ([C@H] (C) [C@@H] (O) [C@@H]1C) =O) O[C@@] ([C@@H]2C) ([H]) [C@H] (C) [C@@]3 (CC[C@H] (C) [C@H] (C[C@H] (O) C) O3) O[C@@]2 ([H]) CC[C@@H] (CC) /C=C/C=C/C[C@@H] (C) [C@H] (O) [C@@] (C) (O) C1=O

• Molecular Formula:

  C45H74O11

• Molecular Weight:

  791.06

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Salomon AR, et al. Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chem Biol. 2001 Jan;8 (1) :71-80.|[2]Ramió-Lluch L, et al. Oligomycin A-induced inhibition of mitochondrial ATP-synthase activity suppresses boar sperm motility and in vitro capacitation achievement without modifying overall sperm energy levels. Reprod Fertil Dev. 2014;26 (6) :883-97.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  579-13-5