Anti-H3R17me2(asym) | Histone H3 (asym-dimethyl Arg17)

• Background:

  Common histone modifications include methylation of lysine and arginine, acetylation of lysine, phosphorylation of threonine and serine, and sumoylation, biotinylation, and ubiquitylation of lysine. In particular,dimetylation of H3 Arg17 (H3 R17Me2)has been linked to gene activation. Coactivator-associated arginine methyltransferase-1 (CARM1) methylates Arg17 with its protein arginine methyltransferase (PRMT) catalytic core. Activation of this modification is linked to transcription hormone response promotors, as well as cell fate regulation. Interestingly, H3 methylation of R17 and R26 contributes to greater pluripotency potential of stem cells, while downregulation of this PTM increases differentiation.

• Host:

  Rabbit

• Reactivity:

  Caenorhabditis elegans, Human

• Not reactive in:

  No confirmed exceptions from predicted reactivity are currently known

• Immunogen:

  KLH-conjugated synthetic peptide

• Clonality:

  Polyclonal

• Applications:

  Chromatin immunoprecipitation (ChIP), Immunofluorescence (IF), Western blot (WB)

• Dilution:

  2-5 µg/million cells (ChIP), 1 : 50 (IF), 1 : 500 (WB)

• Purity:

  Immunogen affinity purified serum.

• Format:

  Liquid

• Molecular Weight:

  15 kDa

• Storage Conditions:

  Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

• CAS Number:

  9007-83-4