(KO Validated) DNMT1 Polyclonal Antibody

CAT: 0866-RD83344A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD83344A-01Size:60 μL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
Description
This is a (KO Validated) DNMT1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNMT1
Gene ID
1786
Swiss Prot
P26358
Reactivity
Human
Immunogen
Recombinant fusion protein of human DNMT1 (NP_001370.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000 IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
144 kDa/183 kDa/184 kDa
Observed Molecular Weight
200 kDa
Host or Source
Rabbit
Isotype
IgG

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