ITGA8 Polyclonal Antibody

• Background :

  Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms.

• Description :

  This is a ITGA8 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  ITGA8

• Gene ID :

  8516

• Swiss Prot :

  P53708

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein of human ITGA8 (NP_003629.2) .

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1 mg/mL

• Dilution :

  WB 1:500-1:2000

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  117 kDa

• Observed Molecular Weight :

  117 kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG