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(KO Validated) BCL10 Polyclonal Antibody

CAT: 0866-RD80512A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD80512A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.
Description
This is a (KO Validated) BCL10 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
BCL10, CARMEN, CIPER, CLAP, IMD37, c-E10, mE10
Gene ID
8915
Swiss Prot
O95999
Reactivity
Human
Immunogen
Recombinant fusion protein of human BCL10 (NP_003912.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
26 kDa
Observed Molecular Weight
33 kDa
Host or Source
Rabbit
Isotype
IgG

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