(KO Validated) BCL10 Polyclonal Antibody

• Background :

  This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

• Description :

  This is a (KO Validated) BCL10 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  BCL10, CARMEN, CIPER, CLAP, IMD37, c-E10, mE10

• Gene ID :

  8915

• Swiss Prot :

  O95999

• Reactivity :

  Human

• Immunogen :

  Recombinant fusion protein of human BCL10 (NP_003912.1) .

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1 mg/mL

• Dilution :

  WB 1:500-1:2000

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  26 kDa

• Observed Molecular Weight :

  33 kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG