IC-87114

• Description :

  IC-87114 is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 μM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  PI3K

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/IC-87114.html

• Purity :

  99.85

• Solubility :

  DMSO : 10 mg/mL (ultrasonic)

• Smiles :

  O=C1N(C(CN2C3=C(C(N)=NC=N3)N=C2)=NC4=CC=CC(C)=C14)C5=C(C)C=CC=C5

• Molecular Formula :

  C22H19N7O

• Molecular Weight :

  397.43

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Sadhu C, et al. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol. 2003 Mar 1;170 (5) :2647-54.|[2]Zheng L, et al. Inactivation of PI3Kδ induces vascular injury and promotes aneurysm development by upregulating the AP-1/MMP-12 pathway in macrophages. Arterioscler Thromb Vasc Biol. 2015 Feb;35 (2) :368-77.|[3]El-Hashim AZ, et al. Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model. Sci Rep. 2017 Aug 30;7 (1) :9919.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PI3Kβ; PI3Kγ; PI3Kδ

• CAS Number :

  [371242-69-2]