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IC 86621

CAT: 0804-HY-100707-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100707-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 μM) . IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis[1][2].
CAS Number
404009-40-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; DNA-PK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ic-86621.html
Purity
99.06
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=CC=C(N2CCOCC2)C=C1O)=O
Molecular Formula
C12H15NO3
Molecular Weight
221.26
Precautions
H302, H315, H319
References & Citations
[1]Chandra G, et al. Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621. Arch Pharm Res. 2012 Mar;35 (4) :639-45.|[2]Shao L, et al. DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. EMBO Mol Med. 2010 Oct;2 (10) :415-27.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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