BD-1 Beta Defensin -1 Rat Recombinant Protein

• Description:

  BD-1 Rat Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 37 amino acids and having a molecular mass of 4.1kDa. The BD-1 is purified by proprietary chromatographic techniques.

• Synonyms:

  Beta-defensin 1; BD-1; rBD-1; Defensin beta 1; Defb1

• Gene Name:

  DEFB1

• UniProt:

  O89117

• Reactivity:

  Rat

• Tissue Specificity:

  Highly expressed in kidney.

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Purification:

  Greater than 95.0% as determined by (a) Analysis by RP-HPLC and (b) Analysis by SDS-PAGE.

• Bioactivity:

  Measured by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 ug/ml.

• Form:

  Sterile Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  2

• Function:

  Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.

• Shipping Conditions:

  Available

• Storage Conditions:

  Lyophilized BD-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BD-1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.

• Other Gene Names:

  Beta-defensin 1

• Subcellular Location:

  Secreted