BD-4 Beta Defensin-4 Rat Recombinant Protein

• Description:

  BD-4 Rat Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 41 amino acids and having a molecular mass of 4.4kDa. The BD-4 is purified by proprietary chromatographic techniques.

• Synonyms:

  Beta-defensin 4; BD-4; BD-2; Defensin; beta 4; RBD-2; RBD-4; Defb4; Defb2; Defb3

• Gene Name:

  DEFB4

• UniProt:

  O88514

• Reactivity:

  Rat

• Tissue Specificity:

  Highly expressed in lung.

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Purification:

  Greater than 97.0% as determined by SDS-PAGE.

• Bioactivity:

  Measured by its antimicrobial activity against E. coli. The ED50 for this effect is typically 5-50µg/ml.

• Form:

  Sterile Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  2

• Function:

  Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells.

• Shipping Conditions:

  Available

• Storage Conditions:

  Lyophilized BD-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BD-4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.

• Other Gene Names:

  Beta-defensin 4

• Subcellular Location:

  Secreted