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L-Leucine-d1

CAT: 0804-HY-N0486S11-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0486S11-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
CAS Number
89836-93-1
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Endogenous Metabolite; mTOR
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
CC(C)C[C@@](N)([2H])C(O)=O
Molecular Formula
C6H12DNO2
Molecular Weight
132.18
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9 (10) :e1003857.|[3]Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond) . 2012 Aug 22;9 (1) :77.|[4]Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61 (2) :409-17.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Chemical Information

L-Leucine-2-D1
CAS Number89836-93-1
PubChem CID10749224
IUPAC Name(2S)-2-amino-2-deuterio-4-methylpentanoic acid
Molecular FormulaC6H13NO2
Molecular Weight132.18
XLogP-1.5
Topological Polar Surface Area63.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count9
Formal Charge0
Complexity101
SMILES
[2H][C@](CC(C)C)(C(=O)O)N
InChI
InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1/i5D
InChIKey
ROHFNLRQFUQHCH-VXNMYXNSSA-N
Chemical Structure
2D Structure
2D structure of L-Leucine-2-D1
CAS: 89836-93-1
CID: 10749224
Formula: C6H13NO2
MW: 132.18
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight132.18
XLogP3-1.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass132.100905403
Monoisotopic Mass132.100905403
Topological Polar Surface Area63.3 Ų
Heavy Atom Count9
Formal Charge0
Complexity101
Isotope Atom Count1
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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