L-Leucine-d2
CAT:
804-HY-N0486S12-02
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
L-Leucine-d2
- CAS Number: 362049-59-0
- UNSPSC Description: L-Leucine-d2 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
- Target Antigen: Endogenous Metabolite; mTOR
- Type: Isotope-Labeled Compounds
- Related Pathways: Metabolic Enzyme/Protease;PI3K/Akt/mTOR
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Metabolic Disease
- Purity: 99.0
- Solubility: H2O : 12.5 mg/mL (ultrasonic)
- Smiles: CC(C)C([2H])([2H])[C@H](N)C(O)=O
- Molecular Weight: 133.187
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.|[3]Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.|[4]Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported