Delta-12-Prostaglandin J2

Delta-12-Prostaglandin J2

• CAS Number: 87893-54-7
• UNSPSC Description: Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation[1][2].
• Target Antigen: Apoptosis; Endogenous Metabolite
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/delta-12-prostaglandin-j2.html
• Purity: 99.0
• Solubility: 10 mM in DMSO
• Smiles: CCCCC[C@H](O)C/C=C1[C@H](C=CC\1=O)C/C=C\CCCC(O)=O
• Molecular Weight: 334.45
• References & Citations: [1]Kim BE, et al. Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by Delta12-prostaglandin J2. Exp Mol Med. 2004;36(5):444-453.
• Shipping Conditions: Blue Ice
• Storage Conditions: Solution, -20°C, 2 years
• Clinical Information: No Development Reported