Products for Research Use Only
RegisterLogin

Anti-Transcription factor E2F8 E2F8 Antibody

CAT: 0519-A02322Size: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0519-A02322Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Boster Bio Anti-Transcription factor E2F8 E2F8 Antibody catalog # A02322. Tested in ELISA, WB applications. This antibody reacts with Human.
Synonyms
Transcription factor E2F8; E2F-8; E2F8;
Gene Name
E2F8
UniProt
A0AVK6
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Applications
WB, ELISA
Purification
E2F8 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Form
Liquid
Function
Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3) . Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.
Molecular Weight
94166 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Transcription factor E2F8
Subcellular Location
Nucleus
Protein Name
Transcription factor E2F8

UniProtKB · A0AVK6

Transcription factor E2F8

E2F8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
A0AVK6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
E2F8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
E2F-8
EC number
—
Processing
—
Secondary accessions
A8K9H3, Q2VPJ3, Q3C1U6, Q5BKY4, Q8N340, Q9H5M0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingRepressor

Biological process

Cell cycleTranscriptionTranscription regulation

Cellular component

Nucleus

PTM

Phosphoprotein

Related Products

CatalogName
A05062Anti-Transcription factor E2F6 E2F6 Antibody
A04195Anti-Transcription factor E2F7 E2F7 Antibody
A03068-1Anti-Transcription factor E2F3 E2F3 Antibody
A00257-1Anti-Transcription factor E2F1 E2F1 Antibody
PA2156Anti-Transcription factor E2F4 E2F4 Antibody Picoband®
PA2142Anti-Transcription factor E2F3 E2F3 Antibody Picoband®
PA1811Anti-Transcription factor E2F6 E2F6 Antibody Picoband®
PA1810Anti-Transcription factor E2F2 E2F2 Antibody Picoband®
PA1560Anti-Transcription factor E2F1 E2F1 Antibody Picoband®
PA2142-carrier-freeAnti-Transcription factor E2F3 E2F3 Antibody Picoband®, Carrier-free

Alternative Products

CatalogName
MBS6414901-01E2F8 (Transcription factor E2F8, FLJ23311) (PE)
MBS6414894-01E2F8 (Transcription factor E2F8, FLJ23311) (FITC)
MBS6414892-01E2F8 (Transcription factor E2F8, FLJ23311) (APC)
MBS6414895-01E2F8 (Transcription factor E2F8, FLJ23311) (HRP)
MBS6414893-01E2F8 (Transcription factor E2F8, FLJ23311) (Biotin)
MBS6414891-01E2F8 (Transcription factor E2F8, FLJ23311) (AP)
E0014-22E2F8 (Transcription factor E2F8, E2F-8)
210571-01E2F8 (Transcription factor E2F8, FLJ23311) discontinued
126120E2F8 (Transcription Factor E2F8, E2F-8, FLJ23311)
MBS9319011-01Human Transcription factor E2F8, E2F8 ELISA Kit

Popular Products