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Anti-Transcription factor E2F6 E2F6 Antibody

CAT: 0519-A05062Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A05062Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Boster Bio Anti-Transcription factor E2F6 E2F6 Antibody catalog # A05062. Tested in WB, IHC, IF, IP, CHIP applications. This antibody reacts with Human, Mouse.
Synonyms
Transcription factor E2F6; E2F-6; E2F6
Gene Name
E2F6
UniProt
O75461
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant full length Human E2F6.
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.
Applications
WB, IHC, IF, IP, ChIP
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
31844 MW
Gene Name Synonym
Transcription factor E2F6
Subcellular Location
Nucleus.
Protein Name
Transcription factor E2F6
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

UniProtKB · O75461

Transcription factor E2F6

E2F6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75461
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
E2F6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
E2F-6
EC number
—
Processing
—
Secondary accessions
A8K2Z8, G5E936, O60544, Q53QY9, Q6Q9Z6, Q7Z2H6
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleTranscriptionTranscription regulation

Molecular function

DNA-bindingRepressor

PTM

Isopeptide bondUbl conjugation

Cellular component

Nucleus

Technical term

Proteomics identificationReference proteome

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