Anti-AP-3 complex subunit sigma-1 AP3S1 Antibody

• Background:

  AP3S1 belongs to the adaptor complexes 3 (AP3) small subunit family which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. AP3 is an heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2) . AP3S1 Interacts with AGAP1 and may play an important role in carcinoma.

• Description:

  Boster Bio Anti-AP-3 complex subunit sigma-1 AP3S1 Antibody (Catalog # A12249) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  CLAPS3, Sigma3A, CLAPS3, AP-3 complex subunit sigma-1, AP-3 complex subunit sigma-3A, Sigma3A-adaptin

• Gene Name:

  AP3S1

• UniProt:

  Q92572

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  At least three isoforms of AP3S1 are known to exist; this antibody will detect the two larger isoforms. AP3S1 antibody is predicted to not cross-react with other AP3 protein family members.

• Immunogen:

  AP3S1 antibody was raised against a 19 amino acid synthetic peptide near the center of human AP3S1. The immunogen is located within the first 50 amino acids of AP3S1.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Present in all adult tissues examined.

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  AP3S1 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

• Molecular Weight:

  21732 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  AP3S1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Adaptor-related protein complex 3, sigma 1 subunit

• Subcellular Location:

  Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

• Prediction Reactivity:

  Bovine

• Protein Name:

  Adaptor-related protein complex 3, sigma 1 subunit