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Rat CNTF Protein

CAT: 0749-PRP1222-01Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0749-PRP1222-01Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ciliary neurotrophic factor (CNTF) is a member of the cytokine family. It is a polypeptide hormone that has the function of promoting the synthesis of neurotransmitters and the growth of neurites in a specific neuronal population. Its action seems to be limited to the nervous system. Ciliary neurotrophic factor (CNTF) exerts its biological effects by activating a multi-subunit receptor complex consisting of an extracellular CNTF-binding subunit (CNTFα) and two transmembrane signaling proteins (glycoprotein gp130 and LIF receptor) . CNTF is thought to be a potent survival factor in neurons and oligodendrocytes and may be associated with reduced tissue destruction during inflammatory episodes. CNTF is also a survival factor for peripheral sensory sympathetic ganglions and ciliary ganglia neurons. CNTF has been reported to have therapeutic potential and to greatly differentiate.
Description
Ciliary neurotrophic factor (CNTF) is a member of the cytokine family. It is a polypeptide hormone that has the function of promoting the synthesis of neurotransmitters and the growth of neurites in a specific neuronal population. Its action seems to be limited to the nervous system. Ciliary neurotrophic factor (CNTF) exerts its biological effects by activating a multi-subunit receptor complex consisting of an extracellular CNTF-binding subunit (CNTFα) and two transmembrane signaling proteins (glycoprotein gp130 and LIF receptor) . CNTF is thought to be a potent survival factor in neurons and oligodendrocytes and may be associated with reduced tissue destruction during inflammatory episodes. CNTF is also a survival factor for peripheral sensory sympathetic ganglions and ciliary ganglia neurons. CNTF has been reported to have therapeutic potential and to greatly differentiate.
Product Name Alternative
Ciliary neurotrophic factor; CNTF; H-CNTF
Gene ID
25707
Accession Number
P20294
Tag
CNTF
Type
Cytokines and proteins
Applications
No tag
Purity
> 97 % as determined by SDS-PAGE
Activity
Measured by its ability to induce proliferation in TF-1 cells. The ED50 for this effect is 0.02748 ng/mL.
Molecular Weight
22.9 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin: <1 EU per μg of the protein as determined by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
The Rat-CNTF protein product should be stored desiccated below -20°C. The protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles
Protein Length
The recombinant Rat CNTF consisting of 200 amino acids and has a calculated molecular mass of 22.9 kDa.It migrates as an approximately 24 kDa band in SDS-PAGE under reducing conditions.
Formulation
Liquid in from sterile 20 mM Tris 50mM NaCl , pH 8.0
Applications Notes
Rat
Other Product Names
Ciliary neurotrophic factor; CNTF; H-CNTF
Recommended Usage
Always centrifuge tubes before opening. It is recommended to diluted the protein using the PBS buffer or Protein storage solution to working concentration
Preparation
E. coli
Accession Number URL
http://www.uniprot.org/uniprot/P20294
AA Sequence
Amino acid sequence derived from the processed form of Rat-CNTF (P20294) (Met 1-Met 200) was expressed

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