Recombinant Mouse Interleukin-2/IL-2 Protein

Recombinant Mouse Interleukin-2/IL-2 Protein

• Background: Interleukin 2 (IL 2), also termed T-cell growth factor, is a member of the cytokine family which includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of this family has a four alpha helix bundle. IL-2 signals through the IL-2 receptor, a complex consisting of tree subunits, termed alpha, beta and gamma. The IL-2 R gamma is shared by cytokine receptors of all members of cytokine family. Mature mouse IL-2 shares 56% and 73% aa sequence identity with human and rat IL-2, respectively. IL-2 is produced by CD4+ T cell, CD8+ T cells, gamma δ T cells, B cells, dendritic cells and eosinophils, and plays a vital role in key function of the immune system, tolerance and immunity, primarily via its potent stimulatory activity for T cells.Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity.
• Abbreviation: Interleukin-2;IL-2
• Synonyms: POIL, OTTHUMP, Aldesleukin, IL 2, Interleukin 2, Involved in regulation of T cell clonal expansion, Lymphokine, OTTHUMP00000164090, POIL2, T Cell Growth Factor, T-cell growth facter, Interleukin-2, IL2, TCGF, T-cell growth factor, Il-2
• CAS Number: 9000-83-3
• UniProt: P04351
• Accession Number: P04351
• Host: E. coli
• Origin Species: Mouse
• Tag: None
• Sequence: Ala21-Gln169
• Applications: Cell culture
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells.The specific activity of Recombinant Mouse IL-2 is ≥1×10⁷ IU/mg.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 17 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.