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TAT-cyclo-CLLFVY

CAT: 0013-GTR19036827Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19036827Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This small molecule selectively inhibits HIF-1 dimerization by disrupting the HIF-1α/HIF-1β protein-protein interaction (IC50 = 1.3 μM), without affecting HIF-2α. It suppresses hypoxia-induced HIF-1 activity, reducing expression of downstream targets like VEGF and CAIX in cancer cell lines, and impairs tubularization in hypoxic HUVECs in vitro.
Field of Research
Epigenetics & Chromatin, Metabolism Research, Signal Transduction
Molecular Weight
2559.1
Storage Conditions
-20°C
Notes
For research use only.

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