Recombinant Rat DDR2 Kinase/CD167b Protein (Fc Tag)
CAT:
763-PKSR030218
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No




Recombinant Rat DDR2 Kinase/CD167b Protein (Fc Tag)
- Background: Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.
- Synonyms: DDR2
- CAS Number: 9000-83-3
- UniProt: B1WC09
- Accession Number: B1WC09
- Host: HEK293 Cells
- Origin Species: Rat
- Tag: C-hFc
- Sequence: Met1-Arg399
- Applications: ELISA
- Purity: > 80 % as determined by reducing SDS-PAGE.
- Bioactivity: Measured by its ability to bind with Rat tail Collagen I in a functional ELISA.
- Reconstitution: Please refer to the printed manual for detailed information.
- Molecular Weight: 110 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.