Recombinant Mouse DDR2 Kinase/CD167b Protein (His Tag)

• Background:

  Discoidin domain receptor-2 (DDR2) is a cell surface tyrosine kinase receptor that can be activated by soluble collagen and has been implicated in diverse physiological functions including organism growth and wound repair. DDR2 binds to and is activated by collagen I, II, III, V, and X, with the notable exception of basement membrane collagen IV. DDR2 is expressed in connective tissues arising from embryonic mesoderm. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling.

• Abbreviation:

  DDR2 Kinase, CD167b

• Synonyms:

  CD167 antigen-like family member B; CD167b; Ddr2; Discoidin domain receptor 2; Discoidin domain-containing receptor 2; Neurotrophic tyrosine kinase; Ntrkr3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10; receptor-related 3; tyro10

• UniProt:

  Q03146

• Accession Number:

  Q62371

• Expression System:

  HEK293 Cells

• Tag:

  C-His

• Sequence:

  Gln24-Arg399

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  43.5 kDa

• Observed Molecular Weight:

  60 - 75 kDa

• Formulation:

  Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
  Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
  Please refer to the specific buffer information in the printed manual.

• Species:

  Mouse