Recombinant Human DDR2 Kinase/CD167b Protein (aa 422-855, His & GST Tag)
CAT:
763-PKSH030420
Size:
50 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human DDR2 Kinase/CD167b Protein (aa 422-855, His & GST Tag)
- Background: Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.
- Synonyms: CD167, MIG20a, NTRKR3, TKT, TYRO10
- CAS Number: 9000-83-3
- UniProt: Q16832
- Accession Number: Q16832
- Host: Baculovirus
- Origin Species: Human
- Tag: N-His-GST
- Sequence: Arg422-Glu855
- Applications: Enzyme
- Field of Research: Cardiovascular;Neuroscience
- Purity: > 95 % as determined by reducing SDS-PAGE.
- Bioactivity: The specific activity was determined to be 8 nmol/min/mg using synthetic AXLtide peptide(CKKSRGDYMTMQIG) as substrate.
- Reconstitution: Not Applicable
- Molecular Weight: 77 kDa
- Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
- Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.