Recombinant Human Interleukin-2/IL-2 Protein (Mutant)

• Background:

  Interleukin-2 (IL-2) is an interleukin; a type of cytokine signaling molecule in the immune system; belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells; NK cells; lymphokine-activated killer cells; monocytes; macrophages and oligodendrocytes. New research has shown that IL-2 mutant reduced toxicity while being more potent at stimulating anti-tumor effector immune cells.

• Abbreviation:

  Interleukin-2; IL-2

• Synonyms:

  IL2; IL-2; TCGF; lymphokine; IL3; IL4; IL5; IL6; Aldesleukin; IL-2lymphokine; interleukin-2; Proleukin; interleukin 2; involved in regulation of T-cell clonal expansion; T cell growth factor; T-cell growth factor; IL 2; IL2; Interleukin 2; interleukin2; Involved in regulation of T cell clonal expansion; Lymphokine; POIL2; T Cell Growth Factor; TCGF

• UniProt:

  P60568

• Accession Number:

  P60568

• Expression System:

  HEK293 Cells

• Tag:

  C-His

• Sequence:

  Ala21-Thr153 (L100F, R101D, L105V, I106V, I112F)

• Applications:

  Cell culture

• Field of Research:

  Immunology

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  50

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  16.5 kDa

• Observed Molecular Weight:

  16&18 kDa

• Species:

  Human