Recombinant Human Interleukin-2/IL-2 Protein (active)

• Background:

  Interleukin-2 (IL-2) is an interleukin; a type of cytokine signaling molecule in the immune system; belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells; NK cells; lymphokine-activated killer cells; monocytes; macrophages and oligodendrocytes.

• Abbreviation:

  Interleukin-2/IL-2

• Synonyms:

  Interleukin-2; IL-2; T-Cell Growth Factor; TCGF; Aldesleukin

• UniProt:

  P60568-1

• Accession Number:

  P60568-1

• Expression System:

  HEK293 cells

• Tag:

  None

• Sequence:

  Ala 21-Thr 153

• Field of Research:

  Immunology

• Endotoxin:

  ≤0.01 EU per μg by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Human IL-2 Protein, Tag Free stimulates proliferation of CTLL-2 cells. The specific activity of Human IL-2 Protein, Tag Free is > 0.60 x 10^7 IU/mg, which is calibrated against human IL-2 WHO International Standard.

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  15.4 kDa

• Observed Molecular Weight:

  14-22 kDa

• Formulation:

  Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

• Species:

  Human