Recombinant Human Eotaxin-3/CCL26 Protein (aa 24-94)

Recombinant Human Eotaxin-3/CCL26 Protein (aa 24-94)

• Background: Chemokine Ligand 26 protein (CCL26) is a novel small cytokine belonging to the CC chemokine family which is involved in immunoregulatory and inflammatory processes. CCL26 is constitutively expressed in thymus; but only transiently expressed in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. CCL26; along with Eotaxin-1 and Eotaxin-2; selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for CCL26 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant CCL26 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines; CCL26 maps to human chromosome 7q11.2; within 40 kilobases of the Eotaxin-2 loci. CCL26 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.
• Abbreviation: Eotaxin-3;CCL26
• Synonyms: C-C Motif Chemokine 26, CC Chemokine IMAC, CCL26, Eotaxin-3, MIP-4-Alpha, Macrophage Inflammatory Protein 4-Alpha, SCYA26, Small-Inducible Cytokine A26, TSC-1, Thymic Stroma Chemokine-1
• CAS Number: 9000-83-3
• UniProt: Q9Y258
• Accession Number: Q9Y258
• Host: E. coli
• Origin Species: Human
• Tag: None
• Sequence: Thr24-Leu94
• Field of Research: immunology
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Not Applicable
• Molecular Weight: 13 kDa
• Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.