Recombinant Human CCL11/Eotaxin Protein

Recombinant Human CCL11/Eotaxin Protein

• Background: C-C Motif Chemokine 11 (CCL11) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. In response to the presence of allergens, CCL11 selectively recruits eosinophils, a prominent feature of allergic inflammatory reactions. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for CCL11 include CCR2, CCR3 and CCR5. However, it has been found that CCL11 has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.
• Abbreviation: CCL11;Eotaxin
• Synonyms: C-C Motif Chemokine 11, CCL11, Eosinophil Chemotactic Protein, Eotaxin, SCYA11, Small-Inducible Cytokine A11
• CAS Number: 9000-83-3
• UniProt: P51671
• Accession Number: P51671
• Host: E. coli
• Origin Species: Human
• Tag: None
• Sequence: Gly24-Pro97
• Field of Research: immunology
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 10 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.