Recombinant Human HMGB1 Protein

Recombinant Human HMGB1 Protein

• Background: High mobility group protein B1 is a member of the HMGB family consisting of three members; HMGB1; HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein; HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile; it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte; T cell; dendritic cell activities in inflammatory responses.
• Abbreviation: HMGB1
• Synonyms: HMG-1, HMG1, HMGB1, High Mobility Group Protein 1, High Mobility Group Protein B1
• CAS Number: 9000-83-3
• UniProt: P09429
• Accession Number: P09429
• Host: E. coli
• Origin Species: Human
• Tag: N-MARI
• Sequence: Pro92-Val176
• Field of Research: epigenetics and nuclear signal
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 13 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.