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Recombinant Human GDNF Protein

CAT: 0763-PKSH032488-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0763-PKSH032488-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a disulfide-linked homodimeric glycoprotein that belongs to the TGF-β superfamily. It has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Human GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein. Mature human GDNF was predicted to contain two 134 amino acid residue subunits. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. Mutations in this gene may be associated with Hirschsprung disease.
Abbreviation
GDNF
Synonyms
ATF; Astrocyte-Derived Trophic Factor; GDNF; Glial Cell Line-Derived Neurotrophic Factor; hGDNF
UniProt
P39905
Accession Number
P39905
Expression System
E.coli
Tag
C-His
Sequence
Ser78-Ile211
Applications
Cell culture
Field of Research
Neuroscience; Developmental Biology
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
50
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
16.0 kDa
Observed Molecular Weight
16 kDa
Species
Human

UniProtKB · P39905

Glial cell line-derived neurotrophic factor

GDNF_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P39905
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GDNF
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hGDNF
EC number
—
Processing
Precursor
Secondary accessions
B7WPK7, O95448, O95449, O95986, Q6FH33, Q96L44, Q9UD32, Q9UD33, Q9UMV2, Q9UP67, Q9UP97
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Disease

Disease variantHirschsprung disease

Molecular function

Growth factor

Cellular component

Secreted

Domain

Signal

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