Recombinant Human CXCL10 Protein

• Background:

  Human C-X-C Motif Chemokine Ligand 10 (CXCL10) is a non-ELR chemokine secreted by various cell types; such as monocytes; endothelial cells and fibroblasts; in response to IFN-γ. CXCL10 functions via chemokine receptor CXCR3. CXCL10 has been attributed to several roles; such as chemoattraction for activated T-lymphocytes; inhibition of angiogenesis; and antitumor activity.

• Abbreviation:

  CXCL10

• Synonyms:

  10 kDa Interferon Gamma-Induced Protein; C-X-C Motif Chemokine 10; CXCL10; Gamma-IP10; INP10; IP-10; SCYB10; Small-Inducible Cytokine B10

• UniProt:

  P02778

• Accession Number:

  P02778

• Expression System:

  E.coli

• Tag:

  N-His

• Sequence:

  Val22-Pro98

• Applications:

  Cell culture

• Field of Research:

  Cancer; immunology

• Endotoxin:

  < 0.1 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 98 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Measure by its ability to chemoattract human PBMCs using a concentration range of 10.0 - 100.0 ng/mL. Note: Results may vary from different PBMC donors.

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  9.5 kDa

• Observed Molecular Weight:

  15 kDa

• Species:

  Human