Products for Research Use Only
RegisterLogin

Recombinant Human DUSP3/VHR Protein

CAT: 0763-PKSH031861Size: 100 µgDry Ice: NoHazardous: No
Product image 1Product image 2Product image 3
1 / 3
CAT#:0763-PKSH031861Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Vaccinia H1-related phosphatase (VHR) is classified as a dual-specificity phosphatase (DUSP) ; and the other name is dual-specificity phosphatase 3 (DUSP3) . DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. Unlike typical DUSPs; VHR lacks mitogen-activated protein kinase (MAPK) -binding domain; and shows poor activity against MAPKs. VHR often act on bisphosphorylated protein substrates; it displays a strong preference for dephosphorylating phosphotyrosine residues over phosphothreonine residues. VHR has been identified as a novel regulator of extracellular regulated kinases (ERKs) . VHR is responsible for the rapid inactivation of ERK following stimulation and for its repression in quiescent cells. VHR is a negative regulator of the Erk and Jnk pathways in T cells and; therefore; may play a role in aspects of T lymphocyte physiology that depend on these kinases.
Synonyms
DUSP3; Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; VHR; Vaccinia H1-related phosphatase
UniProt
P51452
Accession Number
P51452
Expression System
Baculovirus-Insect Cells
Tag
None
Sequence
Met 1-Pro 185
Applications
Enzyme
Field of Research
Signal Transduction; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Measured by hydrolysis of 250 µM 3-O-methyl fluorescein phosphate (OMFP) . The specific activity is > 1.0 µmol/min/m
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
20.6 kDa
Observed Molecular Weight
21 kDa
Species
Human

UniProtKB · P51452

Dual specificity protein phosphatase 3

DUS3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P51452
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DUSP3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.16, 3.1.3.48
Processing
—
Secondary accessions
D3DX45, Q5U0J1, Q8IYJ9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell projectionCiliumCytoplasmCytoskeletonFlagellumNucleus

Molecular function

HydrolaseProtein phosphatase
Product Datasheet
Loading...

Related Products

CatalogName
AN302610L-01Recombinant VHR Monoclonal Antibody
E-AB-65870-01DUSP3 Polyclonal Antibody
PDEH100744-01Recombinant Human CTNNB1 Protein
PKSH032428-01Recombinant Human FIBP Protein
PKSH032291-01Recombinant Human CXCL10 Protein
PKSH032458Recombinant Human Insulin Protein
PKSH031792Recombinant Human S100A1 Protein
PKSH030678Recombinant Human GMFB Protein
PKSH030616Recombinant Human PSPH Protein
PKSH031238Recombinant Human S100A9 Protein

Alternative Products

CatalogName
ATGP1237-020Recombinant human VHR/DUSP3 protein
ARP7555-01Recombinant Human DUSP3 / VHR Protein
P514828DUSP3/VHR Protein (Human)
NBP2-57387PEPVHR/DUSP3 Recombinant Protein Antigen
MBS2557085-01Recombinant Human DUSP3/VHR Protein (N-His)
047075DUSP3/VHR, Recombinant, Human, Active discontinued
P514830DUSP3; VHR Protein (N-His, Human)
ARP7560-01Recombinant Human DUSP3 / VHR Protein (His & GST tag)
P514829DUSP3/VHR Protein (N-His-GST, Human)
047076DUSP3/VHR, Recombinant, Human, His-Tag, GST-Tag discontinued

Popular Products