Recombinant Human S100A1 Protein

CAT: 0763-PKSH031792Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0763-PKSH031792Size:100 µg

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Background

S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells; and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation.This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release; inhibition of microtubule assembly; and inhibition of PKC-mediated phosphorylation.. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1; and recently; S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly; reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies.

Synonyms

S100; S100-alpha; S100A

UniProt

P23297

Accession Number

NP_006262.1

Expression System

E.coli

Tag

None

Sequence

Met 1-Ser 94

Applications

ELISA

Field of Research

Signal Transduction; Tags & Cell Markers; Neuroscience

Endotoxin

Please contact us for more information.

Purity

> 97 % as determined by reducing SDS-PAGE.

Bioactivity

Immobilized recombinant human Fc-S100B at 10 μg/mL (100 μl/well) can bind biotinylated human S100A1 with a linear range of 15.6-250 ng/mL. 3. Measured by its ability to bind human His-S100B in functional ELISA.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

10.5 kDa

Species

Human

UniProtKB · P23297

Protein S100-A1

S10A1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P23297
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: S100A1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B2R5D9, Q5T7Y3

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Cellular component

CytoplasmMitochondrionSarcoplasmic reticulum

PTM

GlutathionylationS-nitrosylation

Domain

Repeat

Product Datasheet

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