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Recombinant Human ESAM Protein

CAT: 0763-PKSH031780Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0763-PKSH031780Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain; as well as a hydrophobic signal sequence; a single transmembrane region; and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall; possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.
Synonyms
W117m
UniProt
Q96AP7
Accession Number
NP_620411.2
Expression System
HEK293 Cells
Tag
None
Sequence
Met 1-Ala 248
Field of Research
Signal Transduction; Tags & Cell Markers; Cardiovascular; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 92 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
24.5 kDa
Observed Molecular Weight
40-45 kDa
Species
Human

UniProtKB · Q96AP7

Endothelial cell-selective adhesion molecule

ESAM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96AP7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ESAM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B4DVN8, Q96T50
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

Cellular component

Cell junctionCell membraneMembraneTight junction

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variantIntellectual disability

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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