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Recombinant Human Dectin-1/CLEC7A Protein

CAT: 0763-PKSH031752Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0763-PKSH031752Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.
Synonyms
BGR; Beta-glucan receptor; CANDF4; CD369; CLEC7A; CLECSF12; CLECSF12DC-associated C-type lectin 1; DECTIN1; DECTIN1CANDF4; Dectin-1; Dectin1
UniProt
Q68D78
Accession Number
NP_072092.2
Expression System
HEK293 Cells
Tag
None
Sequence
Thr66-Met201
Field of Research
Immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
15.5 kDa
Observed Molecular Weight
15 kDa
Species
Human

UniProtKB · Q68D78

Protein information

Q68D78_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q68D78
Review status
UniProtKB unreviewed (TrEMBL)
Gene
DKFZp686L24211
Protein existence
2: Evidence at transcript level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Ligand

Lectin

Cellular component

Membrane

Domain

TransmembraneTransmembrane helix
Product Datasheet
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