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Recombinant Human IL-1α Protein

CAT: 0763-PDMH100025-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0763-PDMH100025-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Abbreviation
IL-1α
Synonyms
IL1F; IL1A; IL-1A; IL1; IL1-ALPHA; IL1F1; BAF; FAF; Hematopoietin 1; Hematopoietin-1; IL 1 alpha; IL 1A; IL1 ALPHA; IL-1 alpha; IL1-A; Interleukin 1 alpha; Interleukin1 alpha; Interleukin-1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha; Pro-Interleukin-1-Alpha
UniProt
P01583
Accession Number
P01583
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met1-Ala271
Field of Research
Cancer; Cardiovascular; Immunology
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
30.6 kDa
Observed Molecular Weight
35 kDa
Species
Human

UniProtKB · P01583

Interleukin-1 alpha

IL1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01583
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-1 alpha
EC number
—
Processing
Precursor
Secondary accessions
Q53QF9, Q7RU02
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinLipoproteinMyristatePhosphoprotein

Molecular function

CytokineMitogenPyrogen

Cellular component

CytoplasmNucleusSecreted

Biological process

Inflammatory response
Product Datasheet
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